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	Provedor de dados BJMBR (1) Autor Cheng,Chang (1) Dong-Feng,Zeng (1) Pei-Yan,Kong (1) Ting,Liu (1) Xi,Zhang (1) Xing-Hua,Chen (1) Xue,Liang (1) Mais... Palavra-chave HIF-1α (1) Human bone marrow stromal cells (hBMSCs) (1) Leukemia (1) RNAi (1) SDF-1α (1) VEGF (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Silencing HIF-1α reduces the adhesion and secretion functions of acute leukemia hBMSCs BJMBR Dong-Feng,Zeng; Ting,Liu; Cheng,Chang; Xi,Zhang; Xue,Liang; Xing-Hua,Chen; Pei-Yan,Kong. Hypoxia inducible factor-1α (HIF-1α) is an important transcription factor, which plays a critical role in the formation of solid tumor and its microenviroment. The objective of the present study was to evaluate the expression and function of HIF-1α in human leukemia bone marrow stromal cells (BMSCs) and to identify the downstream targets of HIF-1α. HIF-1α expression was detected at both the RNA and protein levels using real-time PCR and immunohistochemistry, respectively. Vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1α (SDF-1α) were detected in stromal cells by enzyme-linked immunosorbent assay. HIF-1α was blocked by constructing the lentiviral RNAi vector system and infecting the BMSCs. The Jurkat cell/BMSC co-cultured system... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIF-1α; Human bone marrow stromal cells (hBMSCs); Leukemia; RNAi; SDF-1α; VEGF. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001000004 Registros recuperados: 1 Primeira ... 1 ... Última

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